Irf3 transcription factor
WebTranscription factors IRF3 activates toll-like receptor-independent type I IFN production, which are very important in inducing IFN-γ production. 32 IFN-α/β is one of the most … WebThe downstream signaling pathways from PRR activation phosphorylate ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 …
Irf3 transcription factor
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WebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, … WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of …
WebJun 5, 2024 · Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the role of IRF3 in obesity and obesity-associated disorders remains unclear. Here, we show that IRF3... WebIRF3 → Interferon regulatory factor 3 (IRF-3) Gene name : IRF3 Family name : IRF Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW
WebPreviously, it was shown that IRF3 is a downstream transcription factor that regulates the expression of IFNβ induced by TRIF-dependent TLRs 28, 29. ... 22, via the inhibition of NLRP1 and NLRP3 inflammasome, or via induction of IL-10 who then through activation of STAT3 transcription factor reduced the abundance of pro-IL-1a and pro-IL-1β. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … See more Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. See more IRF3 has been shown to interact with IRF7. See more • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" See more • Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook IRF3 See more
WebNov 1, 2012 · IFN regulatory factor 3 (IRF3) regulates early type I IFNs and other genes involved in innate immunity. We have previously shown that cells undergoing an endoplasmic reticulum (ER) stress response called the unfolded protein response produce synergistically augmented IFN-β when stimulated with pattern recognition receptor …
WebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. … green earth poets cafeWebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … flucht ballon 1979WebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. Mechanistically, IRF3 binds the NF-κB–p65 subunit and prevents its … green earth power thailandWebOct 15, 2024 · Transcription factors for expression of IRF3 engage its gene locus located on human chromosome 19q13.3–13.4 . The structural gene is composed of eight exons, which include a 5′UTR. Several laboratories uncovered critical domains of … green earth power washing llcWebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. flucht bootWebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear … green earth potsWebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … green earth power systems