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WebSep 17, 2024 · You are running a clinical trial for a new treatment for individuals with chronic heart failure. The following inclusion criteria apply: 18 to 80 years of age Diagnosis of chronic heart failure at least 6 months before trial On stable doses of heart failure therapies Willing to return for required follow-up (posttest) visits WebThis sample included 3 pivotal trials for rare diseases that enrolled fewer than 15 patients each at an estimated mean cost of less than $5 million per study. Second, pivotal trials were expensive when the benefits of a new agent were similar to those of agents already available with well-established clinical benefits. The highest-cost trial in ... WebFeb 10, 2024 · These include the same issues that should be considered when evaluating a traditional pairwise meta-analysis, such as the rigor of the literature search, risk of bias among included trials ... chin scratch gif