Hif3a的研究现状
Web53417 Ensembl ENSG00000124440 ENSMUSG00000004328 UniProt Q9Y2N7 Q0VBL6 RefSeq (mRNA) NM_022462 NM_152794 NM_152795 NM_152796 NM_001162950 NM_016868 RefSeq (protein) NP_071907 NP_690007 NP_690008 NP_690009 NP_001156422 NP_058564 Location (UCSC) Chr 19: 46.3 – 46.34 Mb Chr 7: 16.77 – … WebResults: The expression status of HIF3A was notably less in all cancer samples in contrast to their adjacent normal tissues. The expression degree of HIF1A varied among distinct …
Hif3a的研究现状
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Web25 de nov. de 2015 · 生物通报道：氧分子 (O 2)是线粒体ATP和许多细胞内生化反应所必需的一种关键底物，因此其稳态的维持对于大多数物种生存至关重要。在O 2 分子出现匮乏的时候，哺乳动物细胞就会出现多种适应情况，比如低氧诱导因子HIF，mTOR，自噬，以及ER应激反应。. 低氧诱导因子（Hypoxia-Inducible Factors）最早是 ... Weband HIF2a, HIF3a is able to dimerize with HIFb sub-units, and the resulting heterodimer recognizes the HRE on the promoter of target genes (Fig. 2). More-over, the HIF3a–HIFb …
Web30 de out. de 2024 · Summary. The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. WebHIF1A, HIF1B and HIF2A were significantly different in healthy aged tissues, and both HIF1A and HIF3A were positively correlated with aging. Beyond these transcription factor alterations, analysis of patterns of gene expression involved in hypoxic changes in tissues showed specific increases in metabolic pathway hypoxia-inducible genes, ...
Web缺氧诱导因子 3 亚基 α： 由该基因编码的蛋白质是几种 alpha/beta 亚基异二聚体转录因子之一的 alpha-3 亚基，这些转录因子调节许多对低氧张力 (缺氧) 的适应性反应。 alpha-3 亚基缺少在包含 alpha-1 或 alpha-2 亚基的因子中发现的反式激活域。人们认为含有 alpha-3 亚基的因子是缺氧诱导基因表达的负调节 ... Web10 de jul. de 2024 · The HIF3A gene is located on chromosome 19q13.2, which is 43 kb long and comprises 19 exons. 14, 15 To date, ten diverse HIF3A transcripts have been observed. 14-18 It was previously discovered that human HIF-3 α 1 expression was induced by hypoxia 19 and that the HIF-3 α 4 variant was downregulated. 15, 16 Evaluation of …
Web21 de mar. de 2024 · HIF3A (Hypoxia Inducible Factor 3 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF3A include Erythrocytosis, Familial, 4 and … hill sachs syndromeWebWe sampled gingival tissues from rhesus monkeys (Macaca mulatta; 3-25 years old) and total RNA was isolated for microarray analysis. HIF1A, HIF1B and HIF2A were … hill sachs lesion of shoulderWeb25 de nov. de 2024 · Hypoxia-inducible factor (HIF), an αβ dimer, is the master regulator of oxygen homeostasis with hundreds of hypoxia-inducible target genes. Three HIF isoforms differing in the oxygen-sensitive α subunit exist in vertebrates. While HIF-1 and HIF-2 are known transcription activators, HIF-3 has been considered a negative regulator of the … smart box hs codeWeb3.2 HIF3A was downregulated in the omental tissue from GDM patients. To further investigate whether HIF family proteins were involved in the regulation of GDM … smart box containers spokaneWebHIF3A-201: 5908: 613aa: ENSP00000341877.2 . Gene/transcipt that contains an open reading frame (ORF). Protein coding. E9PB04-The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants). GENCODE basic, ENST00000377670.4: HIF3A-003: hill sachs x-rayWeb一些研究表明在各种癌症中 Nrf2 信号通路组成性激活会促进癌细胞的生长和增殖，阻止细胞凋亡，增强癌症干细胞 (CSC) 的自我更新能力，更重要的是，可增强癌细胞的化学耐药性和放射抗性。. 因此，阻断 Nrf2 信号是一种有前途的癌症治疗方法，特别是对于 Nrf2 ... hill safety equipment corpWeb10 de jul. de 2024 · The HIF3A gene is located on chromosome 19q13.2, which is 43 kb long and comprises 19 exons. 14, 15 To date, ten diverse HIF3A transcripts have been … hill sachs lesion physical therapy