WebNov 15, 2024 · DEAD (DDX)/ DEAH (DHX)-box family of putative RNA helicases are enzymes belonging to the SF2 helicase superfamily. These enzymes are essential for … WebDNA helicase: an enzyme that catalyzes the energy-dependent unwinding of the DNA double helix during DNA replication.
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WebAug 4, 2015 · Here we show that an RNA helicase, helicase 1 (HEL-1), extends the lifespan of the roundworm Caenorhabditis elegansby up-regulating the longevity transcription factor forkhead box O (FOXO). Our finding suggests that an RNA helicase can have rather specific roles in animal longevity. WebSep 23, 2024 · DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and …
WebUpregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas. DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3. miR-431 expression was significantly lower in lung cancer (LCa) tissue samples or cell lines compared to adjacent normal tissues or ... WebFeb 24, 2024 · The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role of DDX3X in tumorigenesis and tumour ...
WebOct 1, 2024 · Several DEAD-box RNA helicases have been reported to provide drought tolerance (Table 1). Pea DNA helicase 45 (PDH45) is a dual helicase with DNA and RNA unfolding activity [ 9 ]. Its overexpression in sugarcane stabilizes the cell membrane and activates DREB2-induced stress-responsive genes to provide drought stress tolerance [ … WebOct 19, 2024 · Four DEAD-box RNA helicase genes ( lmo0866, lmo1246, lmo1450, lmo1722) have been identified in L. monocytogenes EGD-e [ 14, 15, 16 ]. However, the precise mechanisms mediated the impact of the different RNA helicases of L. monocytogenes in capacity to grow at low temperature, motility, and other phenotypes …
WebDDX17 DEAD-box helicase 17 [ (takin)] Gene ID: 128048478, updated on 28-Feb-2024. Summary Other designations. probable ATP-dependent RNA helicase DDX17 ...
WebMay 16, 2024 · Asp-Glu-Ala-Asp (DEAD)-box RNA helicase 3 (DDX3), an ATP-dependent RNA helicase, is associated with RNA splicing, mRNA export, transcription, translation, and RNA decay. Recent studies revealed that DDX3 participates in innate immune response during virus infection by interacting with TBK1 and regulating the production of IFN-β. In … cheap tractors with front loadersWebDEAD-box RNA helicases, which also comprise a large family, are also involved in a range of RNA processing events. Since their discovery as nucleic acid unwinding enzymes, … cycle bertrand thieuWebNov 1, 2012 · In this report, we present data, which document that the DEAD-box helicase DDX11, which is required for sister chromatid cohesion, is a crucial gatekeeper for … cheap tradelines to build creditWebIt was shown that several archaeal members expressed DEAD RNA helicases only at lower temperature [165–167]. Alignment and phylogenetic analyses on the core regions of the Methanococcoides burtonii and other bacterial DEAD-box RNA helicases revealed a loose, but consistent, generation of archaeal and bacterial consensus sequences [165]. cycle beerWebDEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. cheap trademark registration indiaWebJul 22, 2011 · DEAD box proteins form the largest helicase family, with 37 members in humans and 26 in Saccharomyces cerevisiae 3, and are … cycle beharWebAug 21, 2024 · Gao, Z. et al. Coupling between the DEAD-box RNA helicases Ded1p and eIF4A. eLife 5, 568 (2016). Google Scholar cycle benefit in kind