WebOct 20, 2024 · Chronic constriction injury (CCI) of the sciatic nerve represents a well-established model of neuropathic pain, and we conducted single-cell RNA-sequencing … WebChronic constriction injury (CCI) is a model of neuropathic pain induced by four loose ligatures around the sciatic nerve. This work aimed to investigate the sensory, affective, …
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Web坐骨神经慢性压迫损伤模型（chronic constriction injury of the sciatic nerve，CCI）是研究神经病理性疼痛最常见的动物模型。 该模型操作简单，易掌握，术后第2天开始便出现 … The chronic constriction injury (CCI) is a partial nerve injury, mostly used in rodents, which is produced by tying several ligatures around a nerve, such that these ligatures slightly constrict the nerve. This induces an incomplete nerve injury, which entails behavioral signs of hyperalgesia in the animals. See more Originally, the model was established in rats (Bennett and Xie 1988), but it has since been successfully used in mice (Sommer et al. … See more After CCI, spontaneous activity develops in all fiber types, but more frequently in myelinated fibers, and can originate from the DRG or directly from the injury site (Xie and Xiao 1990; … See more Obviously, the amount of nerve damage depends upon the degree of nerve constriction by the ligatures, which makes the model quite variable between laboratories. Even if … See more CCI has been claimed to be a model for different human pathological conditions that are associated with neuropathic pain. At present, no single … See more how to reschedule prc renewal appointment
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Webaxotomy and chronic constriction injury (CCI) of the sciatic nerve, as have indications of degenerative changes in the super-ficial dorsal horn (Sugimoto et al., 1990). What has not been established, however, is whether there is any nerve injury-induced loss of inhibition in the superficial dorsal horn, the site of termi- WebJul 16, 2024 · After trauma injury of peripheral nerves, activated glial cells in the dorsal horn of spinal cord play a vital role in maintaining persistent pain states . In model of chronic constriction of the sciatic nerve injury, increasing expression of GFAP in glial cell was found in the sciatic nerve and the dorsal root ganglion (DRG), and suppression ... Web文档翻译; 收录引证; 论文查重 ... ghrelin on pGSK-3β and β-catenin expression when protects against neuropathic pain behavior in rats challenged with chronic constriction injury [O] . Zhiyou Peng, Leiqiong Zha, Meijuan Yang,-1. 机译：生长激素释放肽对慢性压迫损伤大鼠神经病理性疼痛行为的保护作用对 ... north carolina electrical grid map