Chac1 agonist
WebJun 19, 2015 · Mutation or deletion of the CARE site in the human CHAC1 promoter led to slight (∼15%) decreases in activity at baseline and after ER stress agonist treatment. In contrast, CARE mutations in the mouse Chac1 promoter dramatically reduced basal activity (>80%) and prevented induction by tunicamycin. WebNov 29, 2024 · ChaC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) mRNA is differentially expressed in primary human airway epithelial cells from bronchi (hAECBs) from patients with CF and healthy …
Chac1 agonist
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WebAgonists, activators, antagonists and inhibitors Cell lines and Lysates Multiplex miRNA assays Multiplex Assays By research area Cancer Cardiovascular Cell Biology ... paraffin-embedded rat brain tissue … WebCHAC1 is a UPR induced gene. Examinations of A) mRNA expressions of CHAC1, CHOP, C/ EBPβ, GRP78 and control G3PDH in HEK293 cell extracts after treatments with UPR …
WebWe found CHAC1 is down-regulated in KIRC samples when compared with normal samples but up-regulated in KIRC samples with relatively higher malignancy and later stages. Univariate cox analysis and multivariate cox regression analysis were conducted and the results revealed up-regulated CHAC1 is an independent risk factor for poor prognosis of … WebNov 12, 2024 · CHAC1 is a type of cationic transport regulatory protein 1. It has been reported that CHAC1 is also a γ-glutamyl cyclotransferase that can degrade GSH [24, 31], a key antioxidant in cells, which can inhibit ferroptosis [32]. The activation of CHAC1 is related to the ATF4-CHOP cascade reaction in the endoplasmic reticulum [33]. Our study found ...
WebJul 15, 2024 · The present study aimed to determine the effects and mechanism of ChaC glutathione specific γ‑glutamylcyclotransferase 1 (CHAC1) on cell viability and the sensitivity of prostate cancer cells to docetaxel. Compared with non‑tumor human prostate epithelial RWPE‑1 cells, the mRNA and protein levels of CHAC1 significantly decreased in two … WebNov 28, 2024 · Crawford, R. R. et al. Human CHAC1 protein degrades glutathione, and mRNA Induction is regulated by the transcription factors …
WebMar 21, 2024 · CHAC1 (ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1) is a Protein Coding gene. Diseases associated with CHAC1 include Ovarian Embryonal Carcinoma.Among its related pathways are Cellular responses to stimuli and Metapathway biotransformation Phase I and II.Gene Ontology (GO) annotations related to this gene …
WebDec 1, 2024 · CHAC1 is a UPR induced gene. Examinations of A) mRNA expressions of CHAC1, CHOP, C/EBPβ, GRP78 and control G3PDH in HEK293 cell extracts after … do mice really hate the smell of peppermintWebJun 21, 2024 · Background An emerging component of Unfolded Protein Response (UPR) pathway, cation transport regulator homolog 1 (CHAC1) has been conferred with the ability to degrade intracellular glutathione and induce apoptosis, however, many reports have suggested a role of CHAC1 in cancer progression. Our study aimed to investigate … city of amarillo careersWebJun 15, 2016 · Chac1 was first identified as a novel ER stress inducible gene in human aortic endothelial cells treated with oxidized phospholipids 20, 21. Until now, it has been reported that various stimuli ... do michaela and zack stay marriedWebIn summary, CHAC1 may inhibit cell viability and increase the sensitivity of prostate cancer cells to DTX. The cellular mechanism may involve the induction of ER stress … city of amarillo brush siteWebCHAC1 Antibodies. Antibodies that detect CHAC1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, … city of alvord texasWebApr 10, 2024 · RT @InsideWithPsaki: .@GavinNewsom on Gov. Ron DeSantis signing a permitless concealed carry bill into law at a nonpublic event in his office: He’s “scared to death.” @jrpsaki: “Who’s he scared of?” city of amarillo calendarWebJun 21, 2024 · CHAC1 is primarily a cytoplasmic ER stress protein that has an enigmatic role in cancer progression mainly due to its involvement in apoptosis, and hence it was surprising to observe CHAC1 overexpression in tumor samples. city of amarillo budget